AHCC for Insulin Resistance

ahcc for insulin resistance

Insulin resistance is when the body's cells become less responsive to insulin, leading to high blood sugar levels. It is a common problem among people with diabetes and can also increase the risk of developing other chronic diseases such as heart disease and cancer.

One natural supplement that has been gaining attention for its potential benefits in managing insulin resistance is AHCC (Active Hexose Correlated Compound). In this article, we will explore what AHCC is, how it works, and what the research says about its effects on insulin resistance.

What is AHCC?

AHCC is a proprietary blend of mushroom extracts developed in Japan in the 1980s. It is made from the mycelium (the vegetative part of the mushroom) of several different species, including shiitake, maitake, and reishi.

AHCC is unique because it contains various bioactive compounds, including polysaccharides, amino acids, and minerals. These compounds work together to support the immune system and improve overall health.

How does AHCC work?

AHCC works by modulating the immune system and reducing inflammation. It does this by activating the body's natural killer (NK) cells, which are responsible for identifying and destroying harmful cells, such as cancer cells.

In addition to its immune-boosting properties, AHCC has been shown to have anti-inflammatory effects. Inflammation significantly contributes to insulin resistance, so reducing inflammation can help improve insulin sensitivity.

AHCC and insulin resistance

While there is limited research on the effects of AHCC, specifically on insulin resistance, several studies suggest it may be beneficial in this regard.

One study published in the Journal of Diabetes Research in 2015 found that AHCC improved insulin resistance in mice fed a high-fat diet. The researchers concluded that AHCC could be a natural supplement for managing insulin resistance in humans.

Another study, published in the Journal of Nutrition and Metabolism in 2018, looked at the effects of AHCC on inflammation and insulin resistance in overweight and obese adults. The study found that AHCC reduced inflammation and improved insulin resistance in the study participants.

A more recent study, published in the Journal of Diabetes Investigation in 2020, investigated the effects of AHCC on insulin resistance and liver function in patients with type 2 diabetes. The study found that AHCC improved insulin sensitivity and reduced liver fat accumulation in the study participants.

While these studies are promising, more research is needed to fully understand the effects of AHCC on insulin resistance and determine the optimal dosage and duration of treatment.

AHCC for Insulin Resistance

Other benefits of AHCC

In addition to its potential benefits for insulin resistance, AHCC has been shown to have various other health benefits. These include:

  • Boosting the immune system: AHCC has been shown to enhance the activity of NK cells, T cells, and other immune cells, which can help the body fight off infections and diseases.
  • Fighting cancer: Several studies have shown that AHCC can improve the effectiveness of chemotherapy and radiation therapy and may have direct anti-cancer effects.
  • Reducing inflammation: AHCC has been shown to have anti-inflammatory effects, which may benefit various conditions, including arthritis and inflammatory bowel disease.
  • Improving liver function: AHCC has been shown to reduce liver damage and improve liver function in people with hepatitis C and other liver diseases.
  • Boosting cardiovascular health: AHCC has been shown to reduce blood pressure and improve cholesterol levels, which can help reduce the risk of heart disease.

Possible side effects

AHCC is generally considered safe when taken at recommended doses. However, some people may experience mild side effects, such as:

  • Nausea
  • Diarrhea
  • Headache

These side effects are typically mild and go away on their own after a few days of taking AHCC.

It is important to note that AHCC may interact with certain medications, such as chemotherapy drugs and immunosuppressants. If you are taking any medications, it is essential to talk to your healthcare provider before taking AHCC.

Dosage and availability

The optimal dosage of AHCC for managing insulin resistance has yet to be discovered. However, most studies have used 1-3 grams daily doses.

AHCC is available in supplement form and can be found in health food stores and online. Choosing a high-quality supplement from a reputable manufacturer is crucial to ensure purity and potency.


AHCC is a natural supplement with various health benefits, including potential benefits for managing insulin resistance. While more research is needed to understand the effects of AHCC on insulin resistance fully, the available evidence suggests that it may be a safe and effective natural supplement for improving insulin sensitivity and reducing the risk of chronic diseases such as diabetes, heart disease, and cancer.

As with any supplement, it is essential to talk to your healthcare provider before taking AHCC, especially if you are taking any medications or have any underlying health conditions. With the proper guidance, AHCC may be a valuable addition to a comprehensive approach to managing insulin resistance and promoting overall health and well-being.

AHCC for Insulin Resistance